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Index > Protein center > Aanat(Gene name) > Rat
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  • Aanat (Gene name),
  • Serotonin N-acetyltransferase (Protein name ),  SNAT_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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    • Gene name:
    Aanat(Snat);
    Protein name:
    Serotonin N-acetyltransferase(Serotonin acetylase);
    Alternative:
    Aralkylamine N-acetyltransferase(AA-NAT);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Monomer (By similarity). Interacts with YWHAZ; the interaction requires phosphorylation on Thr-29, and modulates the enzymatic activity of AANAT through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT can bind, via the phosphorylated Ser-203 site, the other YWHAZ monomer with similar effect.
    Function:
    Catalyzes the N-acetylation of serotonin into N-acetylserotonin.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    205
    Sequence:
    50:
    MLSIHPLKPE | ALHLPLGTSE | FLGCQRRHTL | PASEFRCLTP | EDATSAFEIE | 
    100:
    REAFISVSGT | CPLHLDEIRH | FLTLCPELSL | GWFEEGCLVA | FIIGSLWDKE | 
    150:
    RLTQESLTLH | RPGGRTAHLH | VLAVHRTFRQ | QGKGSVLLWR | YLHHLGSQPA | 
    200:
    VRRAVLMCEN | ALVPFYEKFG | FQAMGPCAIT | MGSLTFTELQ | CSLRCHTFLR | 
    205:
    RNSGC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Q64666
    UniGene:
    Rn.88180
    KEGG:
    rno:25120
    Pfam:
    PF00583
    String:
    Q64666
    Uniprot:
    Q64666
     
    FOR
    ELISA Kit for Rat Serotonin acetylase
    Cat.:
    E1937r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Rat Serotonin acetylase
    Cat.:
    E1937h
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    Packing:
    96T
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    ELISA Kit for Rat Serotonin acetylase
    Cat.:
    E1937b
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Serotonin acetylase
    Cat.:
    E1937c
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Serotonin acetylase
    Cat.:
    E1937m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Serotonin acetylase
    Cat.:
    U1937m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Serotonin acetylase
    Cat.:
    U1937b
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Serotonin acetylase
    Cat.:
    U1937c
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Serotonin acetylase
    Cat.:
    U1937h
    Price:
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    Manual:
    Looking for manual.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Rat Serotonin acetylase
    Cat.:
    U1937r
    Price:
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    Manual:
    Looking for manual.
    MSDS:
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    Packing:
    96T
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    Polyclonal Antibody for Rat Serotonin acetylase
    Polyclonal Antibody for Rat Serotonin acetylase
    Cat.:
    P1937Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Serotonin acetylase
    Cat.:
    P1937Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Serotonin acetylase
    Polyclonal Antibody for Rat Serotonin acetylase
    Cat.:
    P1937Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Serotonin acetylase
    Monoclonal Antibody for Rat Serotonin acetylase
    Monoclonal Antibody for Rat Serotonin acetylase
    Monoclonal Antibody for Rat Serotonin acetylase
    Monoclonal Antibody for Rat Serotonin acetylase
    Protein for Rat Serotonin acetylase
    Protein for Rat Serotonin acetylase
    Protein for Rat Serotonin acetylase
    Protein for Rat Serotonin acetylase
    Protein for Rat Serotonin acetylase

    R&D Technical Data

    s

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    s
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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤6.8%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤10.7%

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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery

    Recovery was determined by spiking various levels of SNAT into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    94-100

    Plasma

    98

    96-102

     

     

     

     

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    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

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    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of SNAT and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1：2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-108%

    95-102%

    92-107%

    EDTA plasma(n=5)

    94-103%

    96-101%

    93-105%

    95-102%

    heparin plasma(n=5)

    93-104%

     

    94-104%

    95-103%

    91-105%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1：2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    EDTA plasma(n=5)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland."
      Roseboom P.H. , Coon S.L. , Baler R. , McCune S.K. , Weller J.L. , Klein D.C.
      Endocrinology137:3033-3045(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INDUCTION
      strain: Sprague-Dawley.
      tissue: Pineal gland.
    2. 2.
      "Diurnal variation in mRNA encoding serotonin N-acetyltransferase in pineal gland."
      Borjigin J. , Wang M.M. , Snyder S.H.
      Nature378:783-785(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION
      strain: Sprague-Dawley.
      tissue: Pineal gland.
    3. 3.
      Kim T.-D. , Kim K.-T.
      Submitted (2005-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
      tissue: Pineal gland.
    4. 4.
      "Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis."
      Coon S.L. , Roseboom P.H. , Baler R. , Weller J.L. , Namboodiri M.A.A. , Koonin E.V. , Klein D.C.
      Science270:1681-1683(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-205;INDUCTION
      strain: Sprague-Dawley.
      tissue: Pineal gland.
    5. 5.
      "Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis."
      Ganguly S. , Gastel J.A. , Weller J.L. , Schwartz C. , Jaffe H. , Namboodiri M.A. , Coon S.L. , Hickman A.B. , Rollag M. , Obsil T. , Beauverger P. , Ferry G. , Boutin J.A. , Klein D.C.
      Proc. Natl. Acad. Sci. U.S.A.98:8083-8088(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH 14-3-3 PROTEINS
    6. 6.
      "Proteasomal proteolysis in the adrenergic induction of arylalkylamine-N-acetyltransferase in rat pinealocytes."
      Terriff D.L. , Chik C.L. , Price D.M. , Ho A.K.
      Endocrinology146:4795-4803(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEASOMAL PROTEOLYSIS
    7. 7.
      "Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling."
      Bailey M.J. , Coon S.L. , Carter D.A. , Humphries A. , Kim J.S. , Shi Q. , Gaildrat P. , Morin F. , Ganguly S. , Hogenesch J.B. , Weller J.L. , Rath M.F. , Moller M. , Baler R. , Sugden D. , Rangel Z.G. , Munson P.J. , Klein D.C.
      J. Biol. Chem.284:7606-7622(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
    8. 8.
      "N-terminal residues regulate proteasomal degradation of AANAT."
      Huang Z. , Liu T. , Borjigin J.
      J. Pineal Res.48:290-296(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;PROTEASOMAL PROTEOLYSIS;MUTAGENESIS OF LEU-2; LYS-8; CYS-37; CYS-61; LYS-99; LYS-133 AND LYS-168
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